A Simple Mathematical Model of Gastric Neutralization of Antacid in Vivo
نویسندگان
چکیده
EDITORIAL SYNOPSIS Because all the parameters needed to calculate an adequate dose of antacid for patients with peptic ulcer will probably never be known before treatment, a mathematical method is presented of calculating the minimum dose using the data of various authors as regards gastric secretion and emptying. Also studied is the effect of antacids on secretion rate and emptying time. It was found that to be effective in 90%/ of patients, a dose of 50 mEq. neutralizing capacity is adequate for male duodenal ulcer patients and of 26 mEq. for female duodenal ulcer or male gastric ulcer patients. If the patient's basal secretion is known, a dose of neutralizing capacity eight times the secretion rate is adequate.
منابع مشابه
Evaluation of Antacid Activity of Garcinia Indica Fruit Rind by a Modified Artificial Stomach Model
The present study investigates the antacid effect of the aqueous extract of the fruit rind of Garcinia indica (GIE) by using a modified artificial stomach model. The pH of GIE (400 mg/kg and 800 mg/kg) and its neutralizing effect on artificial gastric acid was determined and compared with water and the active control sodium bicarbonate. A modified model of Vatier’s artificial stomach was used t...
متن کاملAssessment of Antisecretory, Gastroprotective, and In-vitro Antacid Potential of Daucus carota in Experimental Rats
OBJECTIVES In Indo China, carrots have been reported to regulate the functions of the stomach and intestines. The objective of the present investigation was to unravel the therapeutic potential of 50% ethanol extract from Daucus carota roots (EDC) on antisecretory, gastroprotective, and in vitro antacid capacity using experimental rats. METHODS Assessment of EDC antisecretory and in vivo anta...
متن کاملComparison of seven Oxethazaine containing antacids available in the Indian market.
OBJECTIVE This in-vitro study was designed to measure the quantity of acid neutralized by a suspension of a commercial antacid available in Indian markets at a labeled dose and to test the concept of the relative effectiveness of 7 different commercial antacids containing Oxethazaine. METHODS A simple back titration methodology was used to determine the acid neutralization capacity (ANC) of a...
متن کاملGastric emptying of two radiolabelled antacids.
The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy. Successful labelling of the antacids was carried out with 99mTc. The stability of the 99mTc-labelled antacids was satisfactory and there was no difference in antacid capacity between the labelled and unlabelled antacids. The studies were carried out on 15 healthy male volunteers. After an e...
متن کامل